1618 Simulated solar radiation (SSR) induced skin inflammation across skin types measured by dynamic optical coherence tomography and laser doppler

Induction of inflammation is one the most apparent acute effects ultraviolet (UV) on skin, but many studies investigate anti-inflammation and anti-photoaging potency topical formulations with UV models mainly recruit skin types I-IV. Despite growing research photoaging cancer V-VI, knowledge biological responses including erythema vascular dynamics, limited. A double-blinded, randomized, controlled clinical study was conducted I-VI to address response a low SSR-dose series on: erythema, color, blood flow/flux, superficial plexus diameter over 4 weeks. 1% hydrocortisone used as positive control for activity. Fifty-three healthy female volunteers received SSR at 0.8x minimal dose (MED calculated based ITA°), 1.0x MED, 1.5x MED followed by 7 days. Results suggested induction varied within sub-skin types. Blood flow, flux, L a* values showed significant increases 24 hours differences among The treated 1.5 site did not show compared untreated site, increased flux value in V-VI. This might elucidate hydrocortisone’s blanching effect increasing flow early stage inflammation. Thus, I-II consistent 0.8-1.0x whereas III-IV V-VI which suggests an adjustment factor determination ITA° III-IV. These results demonstrate possible model treatment window alleviate different We suggest future anti-inflammatory ingredients account variations